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  Suicidal function
of DNA methylation


Hereditary information in all organisms on the Earth is coded in genes by four letters of the genetic alphabet. 60 years ago, the fifth letter (5-methylcytosine, 5mC) was discovered in DNA, it arises as a result of cytosine modification by a special family of enzymes. At present, the DNA methylation reaction seems to be almost completely investigated, except for the main point: the biological role of this genome modification continues to be one of the oldest and most intriguing mysteries in molecular genetics.

On this Web site, various aspects of DNA methylation are discussed as one of the key mechanisms for the age-related self-destruction of genome that responsible for human genetic diseases, aging, and cancer.


 

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